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Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor
Structural studies of integral membrane proteins have been limited by the intrinsic conformational flexibility and the need to stabilize the proteins in solution. Stabilization by mutagenesis was very successful for structural biology of G protein-coupled receptors (GPCRs). However, it requires heav...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970182/ https://ncbi.nlm.nih.gov/pubmed/29802269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26113-0 |
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