PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

Biomarkers and mechanisms of poly (ADP-ribose) polymerase (PARP) inhibitor-mediated cytotoxicity in tumor cells lacking a BRCA-mutant or BRCA-like phenotype are poorly defined. We sought to explore the utility of PARP-1 inhibitor (PARPi) treatment with/without ionizing radiation in muscle-invasive b...

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Pubblicato in:Oncogene
Autori principali: Liu, Qi, Gheorghiu, Liliana, Drumm, Michael, Clayman, Rebecca, Eidelman, Alec, Wszolek, Matthew F., Olumi, Aria, Feldman, Adam, Wang, Meng, Marcar, Lynnette, Citrin, Deborah E., Wu, Chin-Lee, Benes, Cyril H., Efstathiou, Jason A., Willers, Henning
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970015/
https://ncbi.nlm.nih.gov/pubmed/29511347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0130-6
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