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Corticostriatal circuit defects in Hoxb8 mutant mice

Hoxb8 mutant mice exhibit compulsive grooming and hair removal dysfunction similar to humans with the OCD-spectrum disorder, trichotillomania. Since, in the mouse brain, the only detectable cells that label with Hoxb8 cell lineage appear to be microglia, we suggested that defective microglia cause t...

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Publicado en:Mol Psychiatry
Main Authors: Nagarajan, Naveen, Jones, Bryan W., West, Peter J., Marc, Robert, Capecchi, Mario R.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970001/
https://ncbi.nlm.nih.gov/pubmed/28948967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.180
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