Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice

OBJECTIVE: In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease (NASH) is oxidative stress, which leads to the accumulation of highly reactive electrophilic α/β unsaturated aldehydes. The objective of this study was to determine the impact of NASH on protein c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Petersen, Dennis R., Saba, Laura M., Sayin, Volkan I., Papagiannakopoulos, Thales, Schmidt, Edward E., Merrill, Gary F., Orlicky, David J., Shearn, Colin T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969769/
https://ncbi.nlm.nih.gov/pubmed/29799837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198139
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