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Increased Carbonylation of the Lipid Phosphatase PTEN contributes to Akt2 Activation in a Murine Model of Early Alcohol-induced Steatosis
The production of reactive aldehydes such as 4-hydroxynonenal (4-HNE) is a key event in the pathogenesis of alcoholic liver disease which ranges from simple steatosis to fibrosis. The lipid phosphatase PTEN plays a central role in the regulation of lipid metabolism in the liver. In the present study...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859727/ https://ncbi.nlm.nih.gov/pubmed/23872024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.07.011 |
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