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Increased Carbonylation of the Lipid Phosphatase PTEN contributes to Akt2 Activation in a Murine Model of Early Alcohol-induced Steatosis

The production of reactive aldehydes such as 4-hydroxynonenal (4-HNE) is a key event in the pathogenesis of alcoholic liver disease which ranges from simple steatosis to fibrosis. The lipid phosphatase PTEN plays a central role in the regulation of lipid metabolism in the liver. In the present study...

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Bibliografske podrobnosti
Main Authors: Shearn, C.T., Smathers, R.L., Backos, D.S., Reigan, P., Orlicky, D.J., Petersen, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859727/
https://ncbi.nlm.nih.gov/pubmed/23872024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.07.011
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