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Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs

Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown. Using whole-genome sequencing and ultra-deep amplicon r...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Huang, August Yue, Yang, Xiaoxu, Wang, Sheng, Zheng, Xianing, Wu, Qixi, Ye, Adam Yongxin, Wei, Liping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969758/
https://ncbi.nlm.nih.gov/pubmed/29763432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007395
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