Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs

Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown. Using whole-genome sequencing and ultra-deep amplicon r...

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Publicado en:PLoS Genet
Autores principales: Huang, August Yue, Yang, Xiaoxu, Wang, Sheng, Zheng, Xianing, Wu, Qixi, Ye, Adam Yongxin, Wei, Liping
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969758/
https://ncbi.nlm.nih.gov/pubmed/29763432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007395
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