A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis

There are no defined correlates of protection for any intracellular pathogen, including the bacterium Francisella tularensis, which causes tularemia. Evaluating vaccine efficacy against sporadic diseases like tularemia using field trials is problematic, and therefore alternative strategies to test v...

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Udgivet i:PLoS One
Main Authors: De Pascalis, Roberto, Hahn, Andrew, Brook, Helen M., Ryden, Patrik, Donart, Nathaniel, Mittereder, Lara, Frey, Blake, Wu, Terry H., Elkins, Karen L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969757/
https://ncbi.nlm.nih.gov/pubmed/29799870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198140
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