Patients with CD3G mutations reveal a role for human CD3γ in T(reg) diversity and suppressive function

Integrity of the T-cell receptor/CD3 complex is crucial for positive and negative selection of T cells in the thymus and for effector and regulatory functions of peripheral T lymphocytes. In humans, CD3D, CD3E, and CD3Z gene defects are a cause of severe immune deficiency and present early in life w...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Rowe, Jared H., Delmonte, Ottavia M., Keles, Sevgi, Stadinski, Brian D., Dobbs, Adam K., Henderson, Lauren A., Yamazaki, Yasuhiro, Allende, Luis M., Bonilla, Francisco A., Gonzalez-Granado, Luis I., Celikbilek Celik, Seyma, Guner, Sukru N., Kapakli, Hasan, Yee, Christina, Pai, Sung-Yun, Huseby, Eric S., Reisli, Ismail, Regueiro, Jose R., Notarangelo, Luigi D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2018
Aiheet:
Immunobiology and Immunotherapy
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969384/
https://ncbi.nlm.nih.gov/pubmed/29653965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-02-835561
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