Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

PURPOSE: To investigate whether sheets of retina organoids derived from human embryonic stem cells (hESCs) can differentiate, integrate, and improve visual function in an immunodeficient rat model of severe retinal degeneration (RD). METHODS: 3D hESC-derived retina organoids were analyzed by quantit...

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Bibliografiske detaljer
Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: McLelland, Bryce T., Lin, Bin, Mathur, Anuradha, Aramant, Robert B., Thomas, Biju B., Nistor, Gabriel, Keirstead, Hans S., Seiler, Magdalene J.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2018
Fag:
Retinal Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968836/
https://ncbi.nlm.nih.gov/pubmed/29847666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-23646
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