Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction

PURPOSE: To study if human embryonic stem cell–derived photoreceptors could survive and function without the support of retinal pigment epithelium (RPE) after transplantation into Royal College of Surgeons rats, a rat model of retinal degeneration caused by RPE dysfunction. METHODS: CSC14 human embr...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Lin, Bin, McLelland, Bryce T., Aramant, Robert B., Thomas, Biju B., Nistor, Gabriel, Keirstead, Hans S., Seiler, Magdalene J.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2020
Subjects:
Retinal Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509771/
https://ncbi.nlm.nih.gov/pubmed/32945842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.11.34
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