Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

BACKGROUND: Amyloid-β (Aβ) immunotherapy is one of the most promising disease-modifying strategies for Alzheimer’s disease (AD). Despite recent progress targeting aggregated forms of Aβ, low antibody brain penetrance remains a challenge. In the present study, we used transferrin receptor (TfR)-media...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Alzheimers Res Ther
Autors principals: Syvänen, Stina, Hultqvist, Greta, Gustavsson, Tobias, Gumucio, Astrid, Laudon, Hanna, Söderberg, Linda, Ingelsson, Martin, Lannfelt, Lars, Sehlin, Dag
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968497/
https://ncbi.nlm.nih.gov/pubmed/29793530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0377-8
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars