Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

BACKGROUND: Amyloid-β (Aβ) immunotherapy is one of the most promising disease-modifying strategies for Alzheimer’s disease (AD). Despite recent progress targeting aggregated forms of Aβ, low antibody brain penetrance remains a challenge. In the present study, we used transferrin receptor (TfR)-media...

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Dettagli Bibliografici
Pubblicato in:Alzheimers Res Ther
Autori principali: Syvänen, Stina, Hultqvist, Greta, Gustavsson, Tobias, Gumucio, Astrid, Laudon, Hanna, Söderberg, Linda, Ingelsson, Martin, Lannfelt, Lars, Sehlin, Dag
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968497/
https://ncbi.nlm.nih.gov/pubmed/29793530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0377-8
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