Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models

Splicing regulation is an important step of post-transcriptional gene regulation. It is a highly dynamic process orchestrated by RNA-binding proteins (RBPs). RBP dysfunction and global splicing dysregulation have been implicated in many human diseases, but the in vivo functions of most RBPs and the...

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Published in:Hum Mol Genet
Main Authors: Tan, Qiumin, Yalamanchili, Hari Krishna, Park, Jeehye, De Maio, Antonia, Lu, Hsiang-Chih, Wan, Ying-Wooi, White, Joshua J., Bondar, Vitaliy V., Sayegh, Layal S., Liu, Xiuyun, Gao, Yan, Sillitoe, Roy V., Orr, Harry T., Liu, Zhandong, Zoghbi, Huda Y.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968355/
https://ncbi.nlm.nih.gov/pubmed/28007900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw337
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