Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations

Recent studies have suggested that genes longer than 100 kb are more likely to be misregulated in neurological diseases associated with synaptic dysfunction, such as autism and Rett syndrome. These length-dependent transcriptional changes are modest in MeCP2-mutant samples, but, given the low sensit...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Raman, Ayush T., Pohodich, Amy E., Wan, Ying-Wooi, Yalamanchili, Hari Krishna, Lowry, William E., Zoghbi, Huda Y., Liu, Zhandong
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089998/
https://ncbi.nlm.nih.gov/pubmed/30104565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05627-1
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