PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1

Spinocerebellar ataxia type 1 (SCA1) is caused by the expansion of a trinucleotide repeat that encodes a polyglutamine tract in ataxin-1 (ATXN1). The expanded polyglutamine in ATXN1 increases the protein’s stability and results in its accumulation and toxicity. Previous studies have demonstrated tha...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Bondar, Vitaliy V, Adamski, Carolyn J, Onur, Tarik S, Tan, Qiumin, Wang, Li, Diaz-Garcia, Javier, Park, Jeehye, Orr, Harry T, Botas, Juan, Zoghbi, Huda Y
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077814/
https://ncbi.nlm.nih.gov/pubmed/29860311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy200
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