Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain

Autoproteolysis of human erythrocyte calpain-1 proceeds in vitro at high [Ca(2+)], through the conversion of the 80-kDa catalytic subunit into a 75-kDa activated enzyme that requires lower [Ca(2+)] for catalysis. Importantly, here we detect a similar 75 kDa calpain-1 form also in vivo, in human meni...

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Bibliografiske detaljer
Udgivet i:Biosci Rep
Main Authors: De Tullio, Roberta, Franchi, Alice, Martines, Antonino, Averna, Monica, Pedrazzi, Marco, Melloni, Edon, Sparatore, Bianca
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968184/
https://ncbi.nlm.nih.gov/pubmed/29572388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180147
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