Synthetic single domain antibodies for the conformational trapping of membrane proteins

Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for this purpose, but their generation relies on immunizations, which impedes selections in the presence of ligands typically needed to populate...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric AJ, Arnold, Fabian M, Stohler, Peter, Bocquet, Nicolas, Hug, Melanie N, Huber, Sylwia, Siegrist, Martin, Hetemann, Lisa, Gera, Jennifer, Gmür, Samira, Spies, Peter, Gygax, Daniel, Geertsma, Eric R, Dawson, Roger JP, Seeger, Markus A
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2018
Teme:
Biochemistry and Chemical Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967865/
https://ncbi.nlm.nih.gov/pubmed/29792401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34317
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