Synthetic single domain antibodies for the conformational trapping of membrane proteins

Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for this purpose, but their generation relies on immunizations, which impedes selections in the presence of ligands typically needed to populate...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric AJ, Arnold, Fabian M, Stohler, Peter, Bocquet, Nicolas, Hug, Melanie N, Huber, Sylwia, Siegrist, Martin, Hetemann, Lisa, Gera, Jennifer, Gmür, Samira, Spies, Peter, Gygax, Daniel, Geertsma, Eric R, Dawson, Roger JP, Seeger, Markus A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967865/
https://ncbi.nlm.nih.gov/pubmed/29792401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34317
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