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Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children
Dichloroacetate (DCA) is an investigational drug used to treat congenital lactic acidosis and other mitochondrial disorders. Response to DCA therapy in young children may be suboptimal following body weight–based dosing. This is because of autoinhibition of its metabolism, age-dependent changes in p...
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| 出版年: | J Clin Pharmacol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967850/ https://ncbi.nlm.nih.gov/pubmed/28914978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1009 |
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