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Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children
Dichloroacetate (DCA) is an investigational drug used to treat congenital lactic acidosis and other mitochondrial disorders. Response to DCA therapy in young children may be suboptimal following body weight–based dosing. This is because of autoinhibition of its metabolism, age-dependent changes in p...
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| Udgivet i: | J Clin Pharmacol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967850/ https://ncbi.nlm.nih.gov/pubmed/28914978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1009 |
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