Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model

BACKGROUND: Down syndrome (DS) is a genetic disorder caused by presence of extra copy of human chromosome 21. It is characterised by several clinical phenotypes. Motor dysfunction due to hypotonia is commonly seen in individuals with DS and its etiology is yet unknown. Ts1Cje, which has a partial tr...

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Vydáno v:PLoS One
Hlavní autoři: Bala, Usman, Leong, Melody Pui-Yee, Lim, Chai Ling, Shahar, Hayati Kadir, Othman, Fauziah, Lai, Mei-I, Law, Zhe-Kang, Ramli, Khairunnisa, Htwe, Ohnmar, Ling, King-Hwa, Cheah, Pike-See
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967806/
https://ncbi.nlm.nih.gov/pubmed/29795634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197711
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