Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model

BACKGROUND: Down syndrome (DS) is a genetic disorder caused by presence of extra copy of human chromosome 21. It is characterised by several clinical phenotypes. Motor dysfunction due to hypotonia is commonly seen in individuals with DS and its etiology is yet unknown. Ts1Cje, which has a partial tr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bala, Usman, Leong, Melody Pui-Yee, Lim, Chai Ling, Shahar, Hayati Kadir, Othman, Fauziah, Lai, Mei-I, Law, Zhe-Kang, Ramli, Khairunnisa, Htwe, Ohnmar, Ling, King-Hwa, Cheah, Pike-See
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967806/
https://ncbi.nlm.nih.gov/pubmed/29795634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197711
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