Common variant burden contributes to the familial aggregation of migraine in 1,589 families

Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of...

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Publicado no:Neuron
Main Authors: Gormley, Padhraig, Kurki, Mitja I., Hiekkala, Marjo Eveliina, Veerapen, Kumar, Häppölä, Paavo, Mitchell, Adele A., Lal, Dennis, Palta, Priit, Surakka, Ida, Kaunisto, Mari Anneli, Hämäläinen, Eija, Vepsäläinen, Salli, Havanka, Hannele, Harno, Hanna, Ilmavirta, Matti, Nissilä, Markku, Säkö, Erkki, Sumelahti, Marja-Liisa, Liukkonen, Jarmo, Sillanpää, Matti, Metsähonkala, Liisa, Koskinen, Seppo, Lehtimäki, Terho, Raitakari, Olli, Männikkö, Minna, Ran, Caroline, Belin, Andrea Carmine, Jousilahti, Pekka, Anttila, Verneri, Salomaa, Veikko, Artto, Ville, Färkkilä, Markus, Runz, Heiko, Daly, Mark J., Neale, Benjamin M., Ripatti, Samuli, Kallela, Mikko, Wessman, Maija, Palotie, Aarno
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967411/
https://ncbi.nlm.nih.gov/pubmed/29731251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.04.014
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