Common variant burden contributes to the familial aggregation of migraine in 1,589 families

Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of...

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Veröffentlicht in:Neuron
Hauptverfasser: Gormley, Padhraig, Kurki, Mitja I., Hiekkala, Marjo Eveliina, Veerapen, Kumar, Häppölä, Paavo, Mitchell, Adele A., Lal, Dennis, Palta, Priit, Surakka, Ida, Kaunisto, Mari Anneli, Hämäläinen, Eija, Vepsäläinen, Salli, Havanka, Hannele, Harno, Hanna, Ilmavirta, Matti, Nissilä, Markku, Säkö, Erkki, Sumelahti, Marja-Liisa, Liukkonen, Jarmo, Sillanpää, Matti, Metsähonkala, Liisa, Koskinen, Seppo, Lehtimäki, Terho, Raitakari, Olli, Männikkö, Minna, Ran, Caroline, Belin, Andrea Carmine, Jousilahti, Pekka, Anttila, Verneri, Salomaa, Veikko, Artto, Ville, Färkkilä, Markus, Runz, Heiko, Daly, Mark J., Neale, Benjamin M., Ripatti, Samuli, Kallela, Mikko, Wessman, Maija, Palotie, Aarno
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967411/
https://ncbi.nlm.nih.gov/pubmed/29731251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.04.014
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