Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia

Retinoic acid (RA) and arsenic target the t(15;17)(q24;q21) PML/RARA driver of acute promyelocytic leukemia (APL), their combination now curing over 95% patients. We report exome sequencing of 64 matched samples collected from patients at initial diagnosis, during remission, and following relapse af...

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Udgivet i:Nat Commun
Main Authors: Lehmann-Che, Jacqueline, Bally, Cécile, Letouzé, Eric, Berthier, Caroline, Yuan, Hao, Jollivet, Florence, Ades, Lionel, Cassinat, Bruno, Hirsch, Pierre, Pigneux, Arnaud, Mozziconacci, Marie-Joelle, Kogan, Scott, Fenaux, Pierre, de Thé, Hugues
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967331/
https://ncbi.nlm.nih.gov/pubmed/29795382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04384-5
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