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Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine

Although amino acids are known regulators of translation, the unique contributions of specific amino acids are not well understood. We compared effects of culturing HEK293T cells in medium lacking either leucine, methionine, histidine, or arginine on eIF2 and 4EBP1 phosphorylation and measures of mR...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Mazor, Kevin M., Dong, Leiming, Mao, Yuanhui, Swanda, Robert V., Qian, Shu-Bing, Stipanuk, Martha H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967319/
https://ncbi.nlm.nih.gov/pubmed/29795412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26254-2
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