HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

BACKGROUND: HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. RESULTS: Mass spectrometry analysis showed primarily Tat Ser-16 phosph...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Retrovirology
Autori principali: Ivanov, Andrey, Lin, Xionghao, Ammosova, Tatiana, Ilatovskiy, Andrey V., Kumari, Namita, Lassiter, Hatajai, Afangbedji, Nowah, Niu, Xiaomei, Petukhov, Michael G., Nekhai, Sergei
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966876/
https://ncbi.nlm.nih.gov/pubmed/29792216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-018-0422-5
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