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Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles
BACKGROUND: Doxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date. AIM O...
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| 發表在: | Chem Cent J |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer International Publishing
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5966352/ https://ncbi.nlm.nih.gov/pubmed/29796830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0434-1 |
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