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Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

BACKGROUND: Doxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date. AIM O...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Cent J
Main Authors: Ahmad, Niyaz, Ahmad, Rizwan, Alam, Md Aftab, Ahmad, Farhan Jalees
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966352/
https://ncbi.nlm.nih.gov/pubmed/29796830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0434-1
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