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Single-molecule analysis reveals the mechanism of transcription activation in M. tuberculosis
The σ subunit of bacterial RNA polymerase (RNAP) controls recognition of the −10 and −35 promoter elements during transcription initiation. Free σ adopts a “closed,” or inactive, conformation incompatible with promoter binding. The conventional two-state model of σ activation proposes that binding t...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5966222/ https://ncbi.nlm.nih.gov/pubmed/29806016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao5498 |
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