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QSAR analysis of substituent effects on tambjamine anion transporters

The transmembrane anion transport activity of 43 synthetic molecules based on the structure of marine alkaloid tambjamine were assessed in model phospholipid (POPC) liposomes. The anionophoric activity of these molecules showed a parabolic dependence with lipophilicity, with an optimum range for tra...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Knight, Nicola J., Hernando, Elsa, Haynes, Cally J. E., Busschaert, Nathalie, Clarke, Harriet J., Takimoto, Koji, García-Valverde, María, Frey, Jeremy G., Quesada, Roberto, Gale, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964965/
https://ncbi.nlm.nih.gov/pubmed/29899901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03932k
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