Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism

BACKGROUND: Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood. METHODS: We examined the effect of HHT on alternative splicing of Bcl-x and Caspase 9 in various cells using semi-quantitative reverse transcripta...

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Bibliografiske detaljer
Udgivet i:BMC Complement Altern Med
Main Authors: Sun, Qi, Li, Shiyue, Li, Junjun, Fu, Qiuxia, Wang, Zhongyuan, Li, Bo, Liu, Shan-Shan, Su, Zijie, Song, Jiaxing, Lu, Desheng
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964699/
https://ncbi.nlm.nih.gov/pubmed/29788973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12906-018-2233-6
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