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Suppression of Th1 and Th17 Responses and Induction of Treg Responses by IL-18-Expressing Plasmid Gene Combined with IL-4 on Collagen-Induced Arthritis
OBJECTIVES: IL-18 is a proinflammatory cytokine with multiple immunoregulatory properties. We studied the effect of IL-18 gene therapy on the development of murine collagen-induced arthritis (CIA). METHODS: Plasmid pCAGGS-IL-18 along or in combination with IL-10 or IL-4 was administered to CIA mice....
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| 出版年: | Biomed Res Int |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Hindawi
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5964485/ https://ncbi.nlm.nih.gov/pubmed/29854762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5164715 |
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