Suppression of Th1 and Th17 Responses and Induction of Treg Responses by IL-18-Expressing Plasmid Gene Combined with IL-4 on Collagen-Induced Arthritis

OBJECTIVES: IL-18 is a proinflammatory cytokine with multiple immunoregulatory properties. We studied the effect of IL-18 gene therapy on the development of murine collagen-induced arthritis (CIA). METHODS: Plasmid pCAGGS-IL-18 along or in combination with IL-10 or IL-4 was administered to CIA mice....

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Dai, Qiaomei, Li, Yang, Yu, Haiyue, Wang, Xiaoyan
Format: Artigo
Language:Inglês
Published: Hindawi 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964485/
https://ncbi.nlm.nih.gov/pubmed/29854762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/5164715
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