Synthetic cytokine receptors transmit biological signals using artificial ligands

Cytokine-induced signal transduction is executed by natural biological switches, which among many others control immune-related processes. Here, we show that synthetic cytokine receptors (SyCyRs) can induce cytokine signaling using non-physiological ligands. High-affinity GFP- and mCherry-nanobodies...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Engelowski, Erika, Schneider, Artur, Franke, Manuel, Xu, Haifeng, Clemen, Ramona, Lang, Alexander, Baran, Paul, Binsch, Christian, Knebel, Birgit, Al-Hasani, Hadi, Moll, Jens M., Floß, Doreen M., Lang, Philipp A., Scheller, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964073/
https://ncbi.nlm.nih.gov/pubmed/29789554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04454-8
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