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Differences in α-Crystallin isomerization reveal the activity of protein isoaspartyl methyltransferase (PIMT) in the nucleus and cortex of human lenses

Although it is well-known that protein turnover essentially stops in mature lens fiber cells, mapping out the ensuing protein degradation and its effects on lens function over time remains challenging. In particular, isomerization is a common, spontaneous post-translational modification that occurs...

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Detalhes bibliográficos
Publicado no:Exp Eye Res
Main Authors: Lyon, Yana A., Sabbah, Georgette M., Julian, Ryan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964019/
https://ncbi.nlm.nih.gov/pubmed/29571628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.03.018
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