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Structural and functional consequences of age-related isomerization in α-crystallins

Long-lived proteins are subject to spontaneous degradation and may accumulate a range of modifications over time, including subtle alterations such as side-chain isomerization. Recently, tandem MS has enabled identification and characterization of such peptide isomers, including those differing only...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lyon, Yana A., Collier, Miranda P., Riggs, Dylan L., Degiacomi, Matteo T., Benesch, Justin L. P., Julian, Ryan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514633/
https://ncbi.nlm.nih.gov/pubmed/30804217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007052
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