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Identification of Amino Acid Epimerization and Isomerization in Crystallin Proteins by Tandem LC-MS

[Image: see text] Post-translational modifications that do not result in a change in mass are particularly difficult to detect by mass spectrometry. For example, isomerization of aspartic acid or epimerization of any chiral residue within a peptide do not lead to mass shifts but can be identified by...

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Bibliografske podrobnosti
Main Authors: Tao, Yuanqi, Julian, Ryan R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188265/
https://ncbi.nlm.nih.gov/pubmed/25188914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac502296c
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