SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

The establishment and maintenance of pluripotency depend on precise coordination of gene expression. We establish serine-arginine-rich splicing factor 3 (SRSF3) as an essential regulator of RNAs encoding key components of the mouse pluripotency circuitry, SRSF3 ablation resulting in the loss of plur...

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Publicado en:eLife
Autores principales: Ratnadiwakara, Madara, Archer, Stuart K, Dent, Craig I, Ruiz De Los Mozos, Igor, Beilharz, Traude H, Knaupp, Anja S, Nefzger, Christian M, Polo, Jose M, Anko, Minna-Liisa
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963917/
https://ncbi.nlm.nih.gov/pubmed/29741478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37419
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