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Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring

Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA methylation. Although much is known about DNA methylation establishment, DNA de...

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Vydáno v:Development
Hlavní autoři: SanMiguel, Jennifer M., Abramowitz, Lara K., Bartolomei, Marisa S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963867/
https://ncbi.nlm.nih.gov/pubmed/29530881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.160622
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