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Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring

Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA methylation. Although much is known about DNA methylation establishment, DNA de...

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Bibliografische gegevens
Gepubliceerd in:Development
Hoofdauteurs: SanMiguel, Jennifer M., Abramowitz, Lara K., Bartolomei, Marisa S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Ltd 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963867/
https://ncbi.nlm.nih.gov/pubmed/29530881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.160622
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