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Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring

Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA methylation. Although much is known about DNA methylation establishment, DNA de...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Development
Asıl Yazarlar: SanMiguel, Jennifer M., Abramowitz, Lara K., Bartolomei, Marisa S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963867/
https://ncbi.nlm.nih.gov/pubmed/29530881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.160622
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