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Substratum stiffness tunes proliferation downstream of Wnt3a in part by regulating integrin-linked kinase and frizzled-1

The Wnt/β-catenin pathway controls a variety of cellular behaviors, aberrant activation of which are associated with tumor progression in several types of cancer. The same cellular behaviors are also affected by the mechanical properties of the extracellular matrix (ECM) substratum, which induces si...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Han, Siyang, Pang, Mei-Fong, Nelson, Celeste M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963841/
https://ncbi.nlm.nih.gov/pubmed/29588395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.210476
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