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Tissue stiffness and hypoxia modulate the integrin-linked kinase ILK to control breast cancer stem-like cells
Breast tumors are stiffer and hypoxic compared to nonmalignant breast tissue. Here we report that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells (CSC) through modulation of the integrin-linked kinase ILK. Depleting ILK blocked stiffness and hypoxia-depen...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026611/ https://ncbi.nlm.nih.gov/pubmed/27503933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0579 |
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