Deep Sequencing Revealed a CpG Methylation Pattern Associated With ALDH1L1 Suppression in Breast Cancer

Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analy...

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Bibliografski detalji
Izdano u:Front Genet
Glavni autori: Beniaminov, Artemy D., Puzanov, Grigory A., Krasnov, George S., Kaluzhny, Dmitry N., Kazubskaya, Tatiana P., Braga, Eleonora A., Kudryavtseva, Anna V., Melnikova, Nataliya V., Dmitriev, Alexey A.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Genetics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962711/
https://ncbi.nlm.nih.gov/pubmed/29868117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00169
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