Deep Sequencing Revealed a CpG Methylation Pattern Associated With ALDH1L1 Suppression in Breast Cancer

Hypermethylation of promoter CpG islands is generally recognized epigenetic mechanism responsible for gene silencing in cancer. However, molecular details on how this epigenetic mark triggers the process of gene downregulation are still elusive. Here, we used deep bisulfite sequencing and qPCR analy...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Beniaminov, Artemy D., Puzanov, Grigory A., Krasnov, George S., Kaluzhny, Dmitry N., Kazubskaya, Tatiana P., Braga, Eleonora A., Kudryavtseva, Anna V., Melnikova, Nataliya V., Dmitriev, Alexey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962711/
https://ncbi.nlm.nih.gov/pubmed/29868117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00169
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