Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities

Phosphodiesterase 10 is a promising target for the treatment of a series of central nervous system (CNS) diseases. Imbalance between oxidative stress and antioxidant defense systems as a universal condition in neurodegenerative disorders is widely studied as a potential therapy for CNS diseases, suc...

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Detalles Bibliográficos
Publicado en:Front Chem
Autores principales: Li, Jinxuan, Chen, Jing-Yi, Deng, Ya-Lin, Zhou, Qian, Wu, Yinuo, Wu, Deyan, Luo, Hai-Bin
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962708/
https://ncbi.nlm.nih.gov/pubmed/29868568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00167
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