Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages

Idiopathic pulmonary fibrosis is a devastating disease with poor prognosis. The pathogenic role of the lysophospholipid mediator sphingosine-1-phosphate and its receptor S1PR2 in lung fibrosis is unknown. We show here that genetic deletion of S1pr2 strikingly attenuated lung fibrosis induced by repe...

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Veröffentlicht in:PLoS One
Hauptverfasser: Zhao, Juanjuan, Okamoto, Yasuo, Asano, Yuya, Ishimaru, Kazuhiro, Aki, Sho, Yoshioka, Kazuaki, Takuwa, Noriko, Wada, Takashi, Inagaki, Yutaka, Takahashi, Chiaki, Nishiuchi, Takumi, Takuwa, Yoh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962071/
https://ncbi.nlm.nih.gov/pubmed/29782549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197604
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