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Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 — Jekyll Hidden behind Hyde

Sphingosine-1-phosphate (S1P) is a plasma lipid mediator with multiple roles in mammalian development, physiology and pathophysiology. It is constitutively produced mostly by erythrocytes by the action of sphingosine kinase 1 (SphK1), resulting in high (∼0.5 micromolar) steady-state plasma S1P conte...

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Main Authors: Takuwa, Noriko, Du, Wa, Kaneko, Erika, Okamoto, Yasuo, Yoshioka, Kazuaki, Takuwa, Yoh
格式: Artigo
語言:Inglês
出版: e-Century Publishing Corporation 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186046/
https://ncbi.nlm.nih.gov/pubmed/21984966
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