Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells

Increased protein translation in cells and various factors in the tumor microenvironment can induce endoplasmic reticulum (ER) stress, which initiates the unfolded protein response (UPR). We have previously reported that factors released from cancer cells mounting a UPR induce a de novo UPR in bone...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Rodvold, Jeffrey J., Chiu, Kevin T., Hiramatsu, Nobuhiko, Nussbacher, Julia K., Galimberti, Valentina, Mahadevan, Navin R., Willert, Karl, Lin, Jonathan H., Zanetti, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962022/
https://ncbi.nlm.nih.gov/pubmed/28588081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aah7177
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