Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

OBJECTIVE: Myeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in tumour immunity. Here we elucidated the role of tumour-intri...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Gut
Autori principali: Zhou, Jingying, Liu, Man, Sun, Hanyong, Feng, Yu, Xu, Liangliang, Chan, Anthony W H, Tong, Joanna H, Wong, John, Chong, Charing Ching Ning, Lai, Paul B S, Wang, Hector Kwong-Sang, Tsang, Shun-Wa, Goodwin, Tyler, Liu, Rihe, Huang, Leaf, Chen, Zhiwei, Sung, Joseph JY, Chow, King Lau, To, Ka Fai, Cheng, Alfred Sze-Lok
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961939/
https://ncbi.nlm.nih.gov/pubmed/28939663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-314032
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi